MEDIA

Scientific Publications

  1. Chen, C-D, Podvin, S, Gillespie, E, Leeman, S andAbraham, CR. (2007) Insulin Stimulates the Cleavage and Release of the Extracellular Domain of Klotho via ADAM10 and ADAM17, PNAS. 104:19796-801. http://www.ncbi.nlm.nih.gov/pubmed/18056631
  2. Duce, JA, Podvin, S, Hollander, W, Kipling, D, Rosene, DL andAbraham, CR. (2008) Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey. Glia. 56:106-17. http://www.ncbi.nlm.nih.gov/pubmed/17963266
  3. King, GD, Rosene, DL andAbraham, CR. (2012) Promoter methylation and age-related downregulation of klotho in rhesus monkey. Age, Sept. 16. 2011 Epub. 34:1405–1419. http://www.ncbi.nlm.nih.gov/pubmed/21922250
  4. King GD, Huang, MM, Schuman ER, Chen CD, Cuny GD, Glicksman MA,Abraham CR. (2012) Identification of novel small molecules to modulate transcription of Klotho.  J. 441:453-61. http://www.ncbi.nlm.nih.gov/pubmed/21939436
  5. Abraham, CR,Chen, CD, Cuny, GD, Glicksman, MA and Zeldich, E. (2012) Small Molecule Klotho Enhancers as Novel Treatment of Neurodegeneration. Future Medicinal Chemistry. 4:1671-9. http://www.ncbi.nlm.nih.gov/pubmed/22924505
  6. Chen, CD, Sloane, JA, Li, H, Aytan, N, Giannaris, EL, Zeldich, E, Hinman, JD, Dedeoglu, A, Rosene, DL, Bansal, R, Luebke, J, Makoto Kuro-o andAbraham, CR. (2013) The anti-aging protein Klotho enhances oligodendrocyte maturation and myelination of the central nervous system.  Neurosci. January 30, 33:1927-39. http://www.ncbi.nlm.nih.gov/pubmed/23365232
  7. Tucker-Zhou, TB, King, GD, Chen, CD andAbraham, CR. (2013) Biochemical and Functional Characterization of the Klotho VS Polymorphism Implicated in Aging and Disease Risk.  Biol. Chem. 288:36302–36311, December 20, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24217253
  8. Mehi, SJ, Maltare, A,Abraham, CR and King, GD. (2014) MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro. Age. Feb;36(1):141-9. Epub 2013 Jul 2. http://www.ncbi.nlm.nih.gov/pubmed/23818104
  9. Dubal, DB, Yokoyama, JS, Zhu, L, Broestl, L, Worden, K, Wang, D, Sturm, VE, Kim, D. Klein, E. Yu, G-Q, Ho, K, Eilertson, KE, Yu, L, Makoto Kuro-o, M, De Jager, PL, Coppola, G, Small, GW, Bennett, DA, Kramer, JH,Abraham, CR, Miller, BL, Mucke, L. (2014) Life extension factor klotho enhances cognition. Cell Reports. 7:1–12, May 22. http://www.ncbi.nlm.nih.gov/pubmed/24813892
  10. Chen, CD, Hu Li, H, Liang, J, Hixson, K, Zeldich, E, andAbraham, CR. (2014) The Anti-Aging and Tumor Suppressor Protein Klotho Enhances Differentiation of a Human Oligodendrocytic Hybrid Cell Line.  Mol. Neurosci. 55:76-90. Jun 8. http://www.ncbi.nlm.nih.gov/pubmed/24907942
  11. Zeldich, E, Chen, CD, Colvin, TA, Bove-Fenderson, EA, Liang, J, Tucker Zhou TB, Harris, DA andAbraham, CR. (2014) The neuroprotective effect of Klotho is mediated via regulation of members of the redox system.  Biol. Chem. Aug 29;289(35):24700-15. http://www.ncbi.nlm.nih.gov/pubmed/25037225
  12. Chen, C-D, Tung, T-Y, Liang, J, Zeldich, E, Turk, BE, andAbraham, CR. (2014) Identification of cleavage sites leading to the shed form of the anti-aging protein Klotho. Biochemistry. Sep 2;53(34):5579-87. http://www.ncbi.nlm.nih.gov/pubmed/25110992
  13. Dubal, D, Zhu, L, Sanchez, P, Worden, K, Broestl, L, Yu, G-Q, Kim, D, Kuro-o, M,Abraham, CR, Mucke, L. (2015) Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.  Neurosci. 35(6):2358-2371. http://www.ncbi.nlm.nih.gov/pubmed/25673831
  14. Zeldich, E, Chen,CD, Avila,R, Medicetty, S and Abraham, CR. The anti-aging protein Klotho enhances remyelination following cuprizone-induced demyelination. J. Mol. Neurosci http://link.springer.com/article/10.1007/s12031-015-0598-2
  15. Abraham CR, Mullen PC, Tucker-Zhou T, Chen CD, Zeldich E. Klotho Is a Neuroprotective and Cognition-Enhancing Protein. In Gerald Litwack, editor: Klotho, Vol 101, VH, UK: Academic Press, 2016, pp. 215-238.http://www.ncbi.nlm.nih.gov/pubmed/27125744
  16.  Masso, A, Sanchez, A, Bosch, A, Gimenez-Llort, L, Chillon, M (2017), Secreted αKlotho isoform protects against age-dependent memory deficits, Molecular Psychiatry, doi:10.1038/mp.2017.21, https://www.nature.com/mp/journal/vaop/ncurrent/full/mp2017211a.html

Press

  1.  Kogenix Licenses Gene Therapy for Prevention of Age-Related Dementia and Alzheimer’s.

    https://www.newswire.com/news/kogenix-licenses-gene-therapy-for-prevention-of-age-related-dementia-20024631

  2. Gene therapy protects against age-related cognitive, memory deficits

    https://www.sciencedaily.com/releases/2017/10/171031085436.htm

  3. Secreted αKlotho isoform protects against age-dependent memory deficits

    http://www.alzforum.org/news/research-news/brain-specific-klotho-isoform-fortifies-memory